I was aware of the long half life; maybe if I start a trial I should dose every 3 days to play it safe. CDP-Choline, also called citicoline, is a naturally-occuring compound and nootropic that is typically supplemented to improve cognitive performance. Your brain will recognize this, and will respond by downregulating the amount of post-synaptic receptors, decreasing your sensitivity to DA. CDP Choline (also known as Citicoline or Cytidine diphosphocholine) is a potent nootropic and a highly bioavailable choline source that is praised for its ability to cross the blood-brain barrier quickly, improving memory and protecting the brain against memory injury. This was even after controlling for age, sex, and smoking status.20https://www.ncbi.nlm.nih.gov/pubmed/20875835 If you’d rather not read the history, skip down to the bottom for my questions. I've never quite been able to get back to that level of cognitive function. I’m a 38-year-old male and in fairly good health. https://www.ncbi.nlm.nih.gov/pubmed/8372096, https://www.sciencedirect.com/science/article/pii/009130579500169W, https://www.ncbi.nlm.nih.gov/m/pubmed/20504471, https://www.ncbi.nlm.nih.gov/pubmed/2906500, https://www.ncbi.nlm.nih.gov/pubmed/16055952, www.ncbi.nlm.nih.gov/pmc/articles/PMC1908237/, https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1991.tb12471.x, https://www.tandfonline.com/doi/abs/10.1080/10623320600934341, http://www.ncbi.nlm.nih.gov/pubmed/9353595, https://www.sciencedirect.com/science/article/pii/0922410694900817, https://www.ncbi.nlm.nih.gov/pubmed/1352895, https://www.ncbi.nlm.nih.gov/pubmed/11267629, https://www.ncbi.nlm.nih.gov/pubmed/26503310, https://www.mdpi.com/2076-3425/3/1/39/htm, https://www.ncbi.nlm.nih.gov/pubmed/20875835, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044190/, https://www.ncbi.nlm.nih.gov/pubmed/11958969/, https://www.ncbi.nlm.nih.gov/pubmed/26871460, https://www.ncbi.nlm.nih.gov/pubmed/9376541, ttps://www.ncbi.nlm.nih.gov/pubmed/26503310, https://www.ncbi.nlm.nih.gov/pubmed/11981225, How to Upregulate Dopamine Over the Long-Term, Fasoracetam, the Latest Member of the Racetam Family, N-Acetyl Cysteine (NAC) – The Ultimate Brain Health Supplement, Coluracetam, an Exotic Cognitive Enhancer, Alcohol Defense – The Hangover Cure That Actually Works, Red Reishi Mushrooms for Reducing Inflammation, Becomes sensitized to DA by increasing its availability to be absorbed. In rats, D2L receptor densities were increased by 43-96%, which indicated DA supersensitivity.13https://www.sciencedirect.com/science/article/pii/0922410694900817. Of those, the only one with notable side effects is forskolin, so I might suggest being more cautious with that. The only problem is that it will be harder to figure out the optimal doses for everything if you’re taking it all at once. I take them daily by eating 3 whole eggs every morning. And some amino acids as well. By preventing overstimulation of striatal DA receptors, uridine may help promote more stable and consistent levels of circulating DA in the brain. Afterwards, it showed the same results as the previous study; increases in both the post and pre synaptic densities. I’ve lost them and now I’m trying to recollect them once more, so I came across this page. It’s unclear which form of exercise is most effective. Choline is the precursor to the neurotransmitter acetylcholine and can be obtained from foods in the form of phosphatidylcholine. There is now an increasingly large amount of evidence that exercise can increases DA receptor availability in the striatum.11https://www.ncbi.nlm.nih.gov/pubmed/26503310, In one study, exercise was shown to reduce the neurological damage that occurs from methamphetamine abuse. I already take a stack with Alcar, NALT, and P.S. In this study, the goal was to identify the correlation between sunshine exposure and DA levels. Once released, they are absorbed by the post-synaptic neurons as seen at the bottom. Discussion of nootropics and cognitive enhancers. I'd like to hear people's experiences with frequent or daily dosing of strong choline sources. I just happened to see a post talking about the dosing of choline, regarding that too much can lead to a depressing effect. In order to explain this distinction, I will need to provide a brief overview of some key brain mechanisms, namely homeostasis and synaptic transmission. CDP-Choline, also called citicoline, is a naturally-occuring compound and nootropic that is typically supplemented to improve cognitive performance. Antidepressants like Zoloft and Prozac share this mechanism, but act as serotonin reuptake inhibitors instead. My theory, and perhaps I should have explained this better, is that these changes last indefinitely as long as you keep taking the supplement(s). Or do you have to keep taking it? If you can’t do everything at once? My understanding is that they are both choline-providing substances the body makes on the way to manufacturing acetylcholine. After seven months, levels of striatal DA were measured. Pick one? With tianeptine gone now, you’re basically left with uridine/cdp choline, inositol, and forskolin. Anymore than that and the concentration/ mood boosting effects dissipate rapidly. Levels of DA were noted to be upregulated after the eight week period, although a compensatory downregulation of the receptor densities was also noted.12https://www.mdpi.com/2076-3425/3/1/39/htm, The upregulatory effects of exercise on DA levels does not not appear come from modulating receptors. I think what I'll probably do if I ever decide to try another trial is dose on Monday, Wednesday, Saturday, or something like that, and see how I feel in 2 or 3 weeks. As a plentiful source of choline, citicoline helps to transport dopamine, increasing its release into the brain. I just started Nootropic stacking a few weeks ago, I am taking ALCAR, NALT, Citicoline, Lions Mane, Bacopa. Have you found anything to stack particularly well with CDP? But on some level, it would help to know I’m attending to my dopaminergic hygiene. This is a recap of the most interesting news and discussions relating to Parkinson’s Disease this past week. This applies to a lot of supplements actually, Vitamin A is another one that really isn't good to take in pure powder form because it spikes blood levels too fast and fucks with internal production. Sulbutiamine. In order to get the same bang for your buck, you have to push the stakes higher, effectively pulling from an ever shrinking store of dopamine. New comments cannot be posted and votes cannot be cast. Inositol, also referred to as Vitamin B8, is a molecule that is structurally similar to glucose. It’s just scary when that happens. I crave CDP-choline like crazy. The lone study showing a 60hr half life for cdp-choline looks to have made some incorrect assumptions about its metabolism / metabolites. PC is rate-limited so that it just provides the building block for your body to take what it needs to make the right amount ACh without over-loading your brain with a direct precursor like CDP. What Is Citicoline Sodium (CDP Choline Sodium) Citicoline sodium (Cytidine diphosphocholine), also referred to as CDP choline, is a compound that has neuro-protective properties. I still can't really focus, but now feel a very light body sensation, and feel as if I can finally feel happiness. Cdp-choline also has many other positive effects in the brain such as restoring the phospholipid count which is a major component in cell membranes. 2. CDP-choline was discovered in 1955. Would you advise using all these strategies together (obviously uridine and choline; yes)? Inositol is considered a pseudovitamin, as inositol is metaboized in the kidneys from glucose. I too get insanely positive results from CDP- choline but I can't use it more than 3 days a week. This list will include both supplements and physical tasks; I will attempt to explain the mechanisms behind each in relationship to this goal. This was fine while I was on a racetam, but I had been trying to keep cdp choline's dopaminergic sensitization going in lieu of the racetam cycle. As a bountiful source of choline, citicoline aids in the transportation of dopamine, augmenting its release into the brain. I just started taking it today (added to my stack) but it won't be daily. After seven months, levels of striatal DA were measured. Awesome, thank you. The authors mentioned that individual differences in DA function may have acted as a self-selection factor in meditation practice. Otherwise, the worry spirals out of control, turns into anxiety. CDP-Choline. These self-correcting steady-state mechanisms of the brain are not limited to drugs of abuse; the brain is constantly making adjustments to maintain a consistent state, from even the most trivial of activities. So things like Memantine and huperzine A don’t fall into that category because they; as I understand it – are used to ward off tolerance if one uses ADD medications. What is Citicoline? This process is commonly referred to as reuptake inhibition. This means that sunlight is not only essential for synthesizing vitamin D in the body, but also for dopaminergic regulation. Accordingly, uridine has been shown to enhance DA release through potassium channels. Does anyone know the reason behind this? Can you just throw everything in there or is that a BIG NO NO!!:). Additionally, in my macroeconomics class I constantly surprised myself with how verbally fluent and confident I was when discussing the material with my professor in class. Forskolin is an herbal extract that is touted for many alleged health benefits. In rats, striatal DA levels were measured after 6 weeks of supplementation. Studies have found that it protects the brain from damage, boosts the levels of numerous neurotransmitters, and improves memory and learning. I would be very surprised if it is longer than 4hrs. CDP-Choline is available as an oral supplement and intravenous injection. It has many interesting properties that warrant further research, but one of the lesser-known properties of the plant is its effect on DA receptors. However, as the 3rd study indicated, it would appear that forskolin does in fact lead to DA sensitization in the brain through modulatory effects on DA receptor densities. That 60 hour half life given to cdp choline may not be correct btw. One of the things cdp-choline does is it up-regulates dopamine receptor density. The issue with taking numerous supplements all at once is that it’s hard to fine-tune them to figure out the optimal dosage for you, plus it can be hard to pinpoint which substance is working for you and which isn’t. Question: To repair dopamine receptors after chronic adderal use how long do you recommend staying on uridine and what dosage range? While this is a possibility, I find it very unlikely that this accounts for every individual case. She must have been talking about the forskolin extract. Additionally, given that rat lifespans are quite short, 7 months is quite a long time, which suggests these changes may be permanent. More studies are urgently needed. Or do you have to choose between one or the other? The brain is constantly trying to maintain homeostasis: a stable, steady state of equilibrium. My first two weeks i felt amazing, but just the last few days i started to feel a little down. However, CDP-choline does provide neuroprotection for dopaminergic neurons7https://www.tandfonline.com/doi/abs/10.1080/10623320600934341, and this protection play a key role. And well-researched nootropics available, and attention tianeptine gone now, you ’ d rather read... 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